Influenza pandemic intervention planning using InfluSim: pharmaceutical and non- pharmaceutical interventions

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Influenza pandemic intervention planning using InfluSim: pharmaceutical and non- pharmaceutical interventions

BACKGROUND Influenza pandemic preparedness plans are currently developed and refined on national and international levels. Much attention has been given to the administration of antiviral drugs, but contact reduction can also be an effective part of mitigation strategies and has the advantage to be not limited per se. The effectiveness of these interventions depends on various factors which mus...

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Design of non-pharmaceutical intervention strategies for pandemic influenza outbreaks

BACKGROUND As seen during past pandemic influenza outbreaks, pharmaceutical interventions (PHIs) with vaccines and antivirals are the most effective methods of mitigation. However, availability of PHIs is unlikely to be adequate during the early stages of a pandemic. Hence, for early mitigation and possible containment, non-pharmaceutical interventions (NPIs) offer a viable alternative. Also, N...

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The influenza pandemic preparedness planning tool InfluSim

BACKGROUND Planning public health responses against pandemic influenza relies on predictive models by which the impact of different intervention strategies can be evaluated. Research has to date rather focused on producing predictions for certain localities or under specific conditions, than on designing a publicly available planning tool which can be applied by public health administrations. H...

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Non-pharmaceutical public health interventions for pandemic influenza: an evaluation of the evidence base

BACKGROUND In an influenza pandemic, the benefit of vaccines and antiviral medications will be constrained by limitations on supplies and effectiveness. Non-pharmaceutical public health interventions will therefore be vital in curtailing disease spread. However, the most comprehensive assessments of the literature to date recognize the generally poor quality of evidence on which to base non-pha...

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Likely effectiveness of pharmaceutical and non-pharmaceutical interventions for mitigating influenza virus transmission in Mongolia.

OBJECTIVE To assess the likely benefit of the interventions under consideration for use in Mongolia during future influenza pandemics. METHODS A stochastic, compartmental patch model of susceptibility, exposure, infection and recovery was constructed to capture the key effects of several interventions--travel restrictions, school closure, generalized social distancing, quarantining of close c...

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ژورنال

عنوان ژورنال: BMC Infectious Diseases

سال: 2007

ISSN: 1471-2334

DOI: 10.1186/1471-2334-7-76